Patients who are prescribed the antifugal drug Nizoral (ketoconazole) may be at risk of severe liver injuries, according to a warning by the Food and Drug Administration. The agency also warned about a risk of adrenal gland problems and harmful drug interactions with Nizoral. The FDA warning only applied to Nizoral oral tablets, and did not involve topical formulations, including creams, shampoos, foams, or gels that can be applied to the skin.
Based on the dangers associated with taking Nizoral in oral tablet form, the FDA has recommended that the drug should not be used as a first-line treatment against a certain type of fungal infections, called endemic mycoses, for which it is designed to treat. The FDA said that Nizoral should only be used to treat these infections when other anti-fungal treatments are not available or cannot be taken by a patient.
Liver Damage (hepatotoxicity)
According to the FDA warning about Nizoral, patients who are treated with the drug in oral tablet form may be at risk of serious liver injuries. In some cases, liver damage caused by Nizoral may result in a liver transplant or death.
Patients who use Nizoral oral tablets may develop liver damage regardless of how long they have taken the drug or how much they take. Patients who take high doses for a short period of time are just as likely to suffer liver injuries as those who are prescribed smaller doses of the drug over a longer period. Although this liver damage is sometime reversible after a patient has stopped taking Nizoral, in many cases the injuries caused by the antifungal drug may be permanent.
The FDA’s announcement about Nizoral also warns against prescribing the drug to patients with liver disease. However, in many cases, patients who developed liver damage after taking Nizoral had no previous risk factors for liver problems.
Adrenal Gland Problems and Harmful Drug Interactions
The use of Nizoral oral tablets may cause problems with the adrenal glands (small glands found at the top of the kidneys) because of the way the drug can lower the body’s production of a type of hormone known as corticosteroids. These hormones affect the balance of water and electrolytes (salts and minerals) in the body.
Patients with acute adrenal insufficiency may experience sudden pain, severe vomiting, diarrhea, dehydration, low blood pressure, or loss of consciousness. If not treated promptly, acute adrenal insufficiency can be fatal.
Patients taking Nizoral may experience interactions with other medications they are taking. These drug interactions can lead to heart rhythm problems or other serious complications. The FDA has advised doctors who prescribe Nizoral oral tablets to check for the possibility of interactions with medications that a patient is already taking before starting them on treatment with the drug.
Free Legal Consultation About Nizoral Lawsuits
As the FDA’s warning has shown, Nizoral is a serious drug that should only be prescribed in cases where no other treatments are available. If you or a loved one have suffered liver injury, adrenal gland problems, or drug interactions after taking the antifungal drug Nizoral in oral tablet form, you may be eligible to file a lawsuit and seek compensation for your injuries.
The lawyers at Heygood, Orr & Pearson have represented hundreds of clients in pharmaceutical liability cases and other legal matters involving product liability and personal injury. Our attorneys have made it their priority to make sure that drug manufacturers and doctors who negligently prescribe medications to their patients are held accountable for their actions in a court of law.
Heygood, Orr & Pearson is AV-rated, the highest possible rating available from the leading legal rating service. The partners at our law firm—Michael Heygood, Jim Orr and Eric Pearson—have all been selected to the Super Lawyers List, a Thomson Reuters publication, in the state of Texas by their peers for several years running. Our attorneys also handle cases across the country in all 50 states.
For a free legal consultation about your case and to find out if you may be eligible to file a Nizoral lawsuit, contact the lawyers at Heygood, Orr & Pearson by calling toll-free at 1-877-446-9001. You can also reach us by completing the free case evaluation form that is located at the top of this page.